CAS No.: 30220-46-3
巨大戟醇 Catalog No. CSN11206
Synonyms: (-)-Ingenol;(+)-Ingenol;巨大戟醇
Ingenol is a diterpenoid with unique architecture and has derivatives possessing important anticancer activity.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01541553 Actinic Keratosis Phase 3 Completed - - NCT02531295 HIV Human Imm... more >>unodeficiency Virus Collapse << Phase 1 Recruiting November 2020 United States, Utah ... more >> University of Utah Recruiting Salt Lake City, Utah, United States, 84132 Contact: Adam M Spivak, MD 801-585-2031 adam.spivak@hsc.utah.edu Contact: Zachary Mitchell (801) 587-7467 zachary.mitchell@hsc.utah.edu Principal Investigator: Sulggi A Lee, MD PhD Principal Investigator: Adam M Spivak, MD Sub-Investigator: Steven G Deeks, MD Collapse << NCT01541553 - - Completed - - - 更多
- 参考文献
- [1] Armstrong S, Ganote CE. Preconditioning of isolated rabbit cardiomyocytes: effects of glycolytic blockade, phorbol esters, and ischaemia. Cardiovasc Res. 1994 Nov;28(11):1700-6.
- [2] Hasler CM, Acs G, et al. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan 1;52(1):202-8.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 30220-46-3 | 储存条件 |
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| 分子式 | C20H28O5 | 运输 | 蓝冰 | |||||
| 分子量 | 348.43 | 别名 | (-)-Ingenol;(+)-Ingenol;巨大戟醇 | |||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT01541553 | Actinic Keratosis | Phase 3 | Completed | - | - |
| NCT02531295 | HIV Human Imm... more >>unodeficiency Virus Collapse << | Phase 1 | Recruiting | November 2020 | United States, Utah ... more >> University of Utah Recruiting Salt Lake City, Utah, United States, 84132 Contact: Adam M Spivak, MD 801-585-2031 adam.spivak@hsc.utah.edu Contact: Zachary Mitchell (801) 587-7467 zachary.mitchell@hsc.utah.edu Principal Investigator: Sulggi A Lee, MD PhD Principal Investigator: Adam M Spivak, MD Sub-Investigator: Steven G Deeks, MD Collapse << |
| NCT01541553 | - | - | Completed | - | - |
| NCT03508856 | Actinic Keratosis ... more >> Photo-aged Skin Collapse << | Not Applicable | Completed | - | - |
| NCT02385318 | Actinic Keratosis | Phase 3 | Completed | - | - |
| NCT02459795 | Actinic Keratosis | Phase 3 | Completed | - | - |
| NCT02362152 | - | - | Completed | - | Netherlands ... more >> Lievensberg Ziekenhuis Bergen op Zoom, Netherlands, 4624 Collapse << |
| NCT00916006 | - | - | Completed | - | - |
| NCT00916006 | Actinic Keratosis | Phase 3 | Completed | - | United States, California ... more >> Dermatology Research Associates Los Angeles, California, United States, 90045 Dermatology Specialists Inc Oceanside, California, United States, 92056 Skin Surgery Medical Group Inc. San Diego, California, United States, 92117 Conant Medical Group San Francisco, California, United States, 94114 United States, Florida University of Miami, Skin Research Camp Miami, Florida, United States, 33136 United States, Georgia Atlanta Dermatology, Vein & Research Center, LLC Alpharetta, Georgia, United States, 30022 Medaphase Inc Newnan, Georgia, United States, 30263 United States, Illinois Glazer Dermatology Buffalo Grove, Illinois, United States, 60089 United States, Indiana Dawes Fretein Clinical Research Group, LLC Indianapolis, Indiana, United States, 46256 United States, Kentucky Pedia Research LLC Owensboro, Kentucky, United States, 42301 United States, Michigan Hamzavi Dermatology Fort Gratiot, Michigan, United States, 48059 United States, Minnesota Minnesota Clinical Study Center Fridley, Minnesota, United States, 55432 United States, North Carolina Wake Research Associates Raleigh, North Carolina, United States, 27612 United States, Tennessee Dermatology Research Associates Nashville, Tennessee, United States, 37203 United States, Texas J & S Studies, Inc. College Station, Texas, United States, 77845 Dermatology Associates of Tyler Tyler, Texas, United States, 75703 Center for Clinical Studies Webster, Texas, United States, 77598 United States, Utah Dermatology Research Center, Inc. Salt Lake City, Utah, United States, 84124 United States, Virginia Virginia Clinical Research, Inc Norfolk, Virginia, United States, 23507 Australia, New South Wales Southderm Pty Ltd Kogarah, New South Wales, Australia, 2217 St George Dematology and Skin Cancer Centre Kogarah, New South Wales, Australia, 2217 Collapse << |
| NCT00917306 | Actinic Keratosis | Phase 3 | Completed | - | United States, Florida ... more >> Park Avenue Dermatology Orange Park, Florida, United States, 32073 United States, Georgia Medaphase Inc Newnan, Georgia, United States, 30263 Gwinnett Clinical Research Centre Snellville, Georgia, United States, 30078-3250 United States, Michigan Michigan Center for Research Corp Clinton Twp, Michigan, United States, 48038 Henry Ford Health Systems Detroit, Michigan, United States, 48202 United States, New York Dermatology Associates of Rochester Rochester, New York, United States, 14623 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239-4501 United States, Tennessee Dermatology Research Associates Nashville, Tennessee, United States, 37203 Australia, South Australia Dematology on Ward Adelaide, South Australia, Australia, 5006 Australia, Victoria Dermatology Institute of Victoria Melbourne, Victoria, Australia, 3141 Australia, Western Australia St John of God Dermatology Subiaco, Western Australia, Australia, 6008 Collapse << |
| NCT02281682 | Keratosis, Actinic | Phase 4 | Active, not recruiting | December 2018 | Netherlands ... more >> Maastricht UMC Maastricht, Limburg, Netherlands, 6202 AZ Collapse << |
| NCT01387711 | Actinic Keratosis | Phase 1 | Completed | - | Germany ... more >> Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Germany, D-37075 Collapse << |
| NCT01449513 | - | - | Completed | - | - |
| NCT02723721 | Lentigo Maligna | Phase 2 | Recruiting | November 2020 | France ... more >> AP-HP Hopital Avicenne Not yet recruiting Bobigny, France, 93000 Contact: Liliane LAROCHE, PU-PH AP-HP Hôpital Ambroise Paré Not yet recruiting boulogne Billancourt, France Contact: Philippe SAIAG, PH Hôpital du Morvan Not yet recruiting Brest, France Contact: Laurent MISERY, PU-PH CHRU de Lille Recruiting Lille, France Contact: Laurent MORTIER, PU-PH CHU de Nantes Not yet recruiting Nantes, France Contact: Brigitte DRENO, PU-PH CHU de Nice Recruiting Nice, France, 06000 Principal Investigator: Henri MONTAUDIE, PH Hôpital Pontchaillou Not yet recruiting Rennes, France Contact: Alain DUPUY, PU-PH CHU de Saint Etienne Recruiting Saint Etienne, France Contact: Frederic CAMBAZARD, PU-PH Collapse << |
| NCT03546166 | Carcinoma | Phase 2 | Not yet recruiting | June 2020 | - |
| NCT01214577 | Photo-damage | Phase 2 | Completed | - | Australia, Queensland ... more >> The Skin Centre Benowa, Queensland, Australia, 4217 Specialist Connect Woolloongabba, Queensland, Australia, 4102 Collapse << |
| NCT00742391 | - | - | Completed | - | - |
| NCT02446223 | Actinic Keratosis | Phase 4 | Completed | - | United States, California ... more >> Cosmetic Laser Dermatology San Diego, California, United States, 92121 Collapse << |
| NCT00915551 | Actinic Keratosis | Phase 3 | Completed | - | - |
| NCT01449513 | Actinic Keratosis | Phase 1 | Completed | - | Germany ... more >> Charité - Universitätsmedizin Berlin Berlin, Germany, 10117 Collapse << |
| NCT00915551 | - | - | Completed | - | - |
| NCT00850811 | Actinic Keratosis | Phase 1 | Completed | - | United States, New Jersey ... more >> TKL Research, Inc. Paramus, New Jersey, United States, 07652 Collapse << |
| NCT00942604 | Actinic Keratoses | Phase 3 | Completed | - | United States, Arizona ... more >> Burke Pharmaceutical Research Hot Springs, Arizona, United States, 71913 United States, California Skin Surgery Medical Group Inc. San Diego, California, United States, 92117 United States, Georgia Atlanta Dermatology, Vein & Research Center, LLC Alpharetta, Georgia, United States, 30022 United States, Illinois Altman Dermatology Associates Arlington Heights, Illinois, United States, 60005 Glazer Dermatology Buffalo Grove, Illinois, United States, 60089 United States, Indiana Deaconess Clinic Downtown Evansville, Indiana, United States, 47713 Dawes Fretzin Clinical Research Group, LLC Indianapolis, Indiana, United States, 46256 United States, Nebraska Skin Specialists, PC Omaha, Nebraska, United States, 68144 United States, Nevada Karl G. Heine Dermatology Henderson, Nevada, United States, 89002 United States, Ohio Group Health Associates Cincinnati, Ohio, United States, 45220 United States, Texas DermResearch, Inc. Austin, Texas, United States, 78759 Suzanne Bruce and Associates, PA, The Center for Skin Research Houston, Texas, United States, 77056 Dermatology Clinical Research Center of San Antonio San Antonio, Texas, United States, 78229 Dermatology Associates of Tyler Tyler, Texas, United States, 75703 United States, Utah Dermatology Research Center, Inc. Salt Lake City, Utah, United States, 84124 United States, Virginia The Education and Research Foundation Lynchburg, Virginia, United States, 24501 Virginia Clinical Research, Inc Norfolk, Virginia, United States, 23507 Collapse << |
| NCT00742391 | Actinic Keratoses | Phase 3 | Completed | - | United States, Arizona ... more >> Omni Dermatology Research Mesa, Arizona, United States, 85206 United States, Colorado Colorado Medical Research Center Denver, Colorado, United States, 80210 United States, Florida Advanced Dermatology and Cosmetic Research Kissimmee, Florida, United States, 34741 Park Avenue Dermatology Orange Park, Florida, United States, 32073 Advanced Dermatology & Cosmetic Surgery Ormond Beach, Florida, United States, 32174 United States, Georgia Medaphase Inc Newnan, Georgia, United States, 30263 Gwinnett Clinical Research Centre Snellville, Georgia, United States, 30078-3250 United States, Indiana Dermatology Center of Indiana/Indiana Clinical Trials Center Plainfield, Indiana, United States, 46168 United States, Michigan Henry Ford Health Systems Detroit, Michigan, United States, 48202 United States, New Jersey Karen S. Harkaway, MD. LLC South Delran, New Jersey, United States, 08075 United States, New Mexico Academic Dermatology Associates Albuquerque, New Mexico, United States, 87106 United States, New York Dermatology Associates of Rochester Rochester, New York, United States, 14623 United States, Ohio University Hospitals Case Medical Center Cleveland, Ohio, United States, 44121 United States, Oregon Oregon Medical Research Portland, Oregon, United States, 97223 Oregon Health and Science University Portland, Oregon, United States, 97239-4501 United States, Tennessee Dermatology East Germantown, Tennessee, United States, 38138 Rivergate Dermatology and Skin Care Center Goodlettsville, Tennessee, United States, 37072 United States, Texas J & S Studies, Inc. College Station, Texas, United States, 77845 Australia, Queensland The Skin Centre Benowa, Queensland, Australia, 4217 Australia, Western Australia Burswood Dermatology Victoria Park, Western Australia, Australia, 6100 Collapse << |
| NCT01214564 | Seborrheic Keratosis | Phase 2 | Completed | - | Australia, New South Wales ... more >> Southderm Pty Ltd Kogarah, New South Wales, Australia, 2217 Australia, Queensland Specialist Connect Woolloongabba, Queensland, Australia, 4102 Collapse << |
| NCT00942604 | - | - | Completed | - | - |
| NCT01302925 | Healthy Actin... more >>ic Keratosis Collapse << | Phase 1 | Completed | - | United States, New Jersey ... more >> TKL Research Paramus, New Jersey, United States Collapse << |
| NCT01325688 | Superficial Basal Cell Carcino... more >>ma Collapse << | Phase 2 | Completed | - | Australia, New South Wales ... more >> Southderm Pty Ltd Kogarah, New South Wales, Australia, 2217 St George Dermatology Kogarah, New South Wales, Australia, 2217 Australia, Queensland The Skin Centre Benowa, Queensland, Australia, 4217 Specialist Connect Woolloongabba, Queensland, Australia, 4102 Australia, Victoria Dermatology Institute of Victoria South Yarra, Victoria, Australia, 3141 Australia, Western Australia St John of God Dermatology Subiaco, Western Australia, Australia, 6008 Burswood Dermatology Victoria Park, Western Australia, Australia, 6100 Collapse << |
| NCT01820260 | Actinic Keratosis | Phase 1 Phase 2 | Completed | - | United States, Indiana ... more >> Laser & Skin Surgery Center of Inidana Carmel, Indiana, United States, 46032 Collapse << |
| NCT01998984 | Actinic Keratosis | Phase 2 | Completed | - | United States, New York ... more >> Long Island Skin Cancer and Dermatologic Surgery Smithtown, New York, United States Collapse << |
| NCT01892137 | Actinic Keratosis | Phase 1 | Completed | - | Australia, New South Wales ... more >> Southderm Pty Ltd Kogarah, New South Wales, Australia, 2217 Melanoma Institute Australia north Sydney, New South Wales, Australia, 2060 Australia, Queensland The Skin Centre Benowa, Queensland, Australia, 4217 South East Dermatology Centre Carina Heights, Queensland, Australia, 4152 Australia, Western Australia St John of God Dermatology Subiaco, Western Australia, Australia, 6008 Burswood Dermatology Victoria Park, Western Australia, Australia, 6100 Germany Klinik für Dermatologie & Allergologie Klinikum Augsburg Süd Augsburg, Germany, 86179 Collegium Medicum Berlin GmbH Berlin, Germany, 10117 Medizinisches Zentrum Bonn Friedensplatz Bonn, Germany, 42275 Hautarztpraxis Prof. Dr. med. C. Termeer Stuttgart, Germany, 70499 Collapse << |
| NCT01998984 | - | - | Completed | - | - |
| NCT00850681 | Actinic Keratosis | Phase 1 | Completed | - | United States, New Jersey ... more >> TKL Research, Inc. Paramus, New Jersey, United States, 07652 Collapse << |
| NCT02090465 | - | - | Unknown | April 2014 | Germany ... more >> Universitätsklinikum Heidelberg/Klinische Sozialmedizin Recruiting Heidelberg, Germany, D-69115 Contact: Thomas L. Diepgen, Prof.Dr.med. +49 6221568751 thomas.diepgen@med.uni-heidelberg.de Principal Investigator: Thomas L Diepgen, Prof.Dr.med. Collapse << |
| NCT02361216 | Actinic Keratosis | Phase 3 | Completed | - | United States, Indiana ... more >> Laser & Skin Surgery Center of Indiana Carmel, Indiana, United States, 46032 Collapse << |
| NCT02361216 | - | - | Completed | - | - |
| NCT02124239 | Actinic Keratosis | Phase 1 | Completed | - | United States, New Mexico ... more >> Academic Dermatology Associate Albuquerque, New Mexico, United States, 47106 Collapse << |
| NCT02654769 | Actinic Keratosis | Phase 3 | Completed | - | United States, California ... more >> Center for Dermatology Clinical Research, Inc Fremont, California, United States, 94538 SD Sports Medicine & Family Health Center San Diego, California, United States, 92120 United States, Florida The Center for Clinical and Cosmetic Research Aventura, Florida, United States, 33180 Savin Medical Group Research Center Miami Lakes, Florida, United States, 33014 Tory P. Sullivan, M.D., P.A. North Miami Beach, Florida, United States, 33162 Moore Clinical Research, Inc. Tampa, Florida, United States, 33609 United States, Idaho Northwest Clinical Trials, Inc. Boise, Idaho, United States, 83704 United States, Illinois Altman Dermatology Associates Arlington Heights, Illinois, United States, 60005 Christie Clinic, LLC Champaign, Illinois, United States, 61820 United States, Indiana Shideler Clinical Research Center Carmel, Indiana, United States, 46032 Dawes Fretzin Clinical Research Group, LLC Indianapolis, Indiana, United States, 46256 The Indiana Clinical Trials Center Plainfield, Indiana, United States, 46168 United States, Nevada Bettencourt Skin Center Henderson, Nevada, United States, 89074 United States, New York Union Square Dermatology New York, New York, United States, 10003 United States, North Carolina Dermatology Consulting Services High Point, North Carolina, United States, 27262 PMG Research of Winston-Salem, LLC Winston-Salem, North Carolina, United States, 27103 United States, Rhode Island Omega Medical Research, 400 Bald Hill Road, Warwick, RI 02886 Warwick, Rhode Island, United States, 02886 United States, South Carolina Greenville Dermatology, LLC Greenville, South Carolina, United States, 29607 United States, Tennessee Dermatology Associates of Knoxville, PC Knoxville, Tennessee, United States, 37917 United States, Texas DermResearch, Inc.Austin Austin, Texas, United States, 78759 The Center for Skin Research Houston, Texas, United States, 77056 United States, Virginia Virginia Clinical Research Norfolk, Virginia, United States, 23507 Collapse << |
| NCT02406014 | Actinic Keratosis (AK) | Phase 4 | Completed | - | Germany ... more >> Gemain, Weber & Craninic Schweinfurt, Germany, 97421 Collapse << |
| NCT03200912 | ACTINIC KERATOSIS | Phase 3 | Completed | - | - |
| NCT01735942 | Actinic Keratosis | Early Phase 1 | Withdrawn | May 2016 | - |
| NCT02242747 | Actinic Keratosis | Not Applicable | Completed | - | Brazil ... more >> Hospital das Clínicas of the University of São Paulo Medical School (HCFMUSP) Sao Paulo, Brazil, 05403000 Collapse << |
| NCT01803477 | Actinic Keratosis | Phase 1 Phase 2 | Completed | - | Australia, Queensland ... more >> Dermatology Department Woolloongabba, Queensland, Australia, 4102 Specialist Connect Woolloongabba, Queensland, Australia, 4102 Collapse << |
| NCT03569345 | Carcinoma, Basal Cell | Phase 1 Phase 2 | Completed | - | Denmark ... more >> Department of Dermtology, Bispebjerg University Hospital, Copenhagen, Denmark Copenhagen, Denmark, 2400 Collapse << |
| NCT00852137 | - | - | Completed | - | - |
| NCT01600014 | Actinic Keratosis | Phase 3 | Completed | - | Australia ... more >> St John of God Dermatology Subiaco, Australia, 6008 Canada, Alberta Stratica Medical Edmonton, Alberta, Canada, T5K 1X3 Canada, British Columbia Skin Care Centre Vancouver, British Columbia, Canada, V5Z 4E8 Canada, Manitoba Dermadvances Research Winnipeg, Manitoba, Canada, R3C 1R4 Canada, New Brunswick Durondel C.P. Inc./Dermatology Clinic Moncton, New Brunswick, Canada, E1C 8X3 Canada, Ontario UltraNova Skincare Barrie, Ontario, Canada, L4M 6L2 SKiN Centre for Dermatology Peterborough, Ontario, Canada, K9J 1Z2 Windsor Clinical Research Inc. Windsor, Ontario, Canada, N8W 5L7 Canada, Quebec Innovaderm Research Inc. Montreal, Quebec, Canada, H2K 4L5 Canada Centre de Recherche Dermatologique Quebec, Canada, G1V 4X7 France CHU de Nantes Nantes, Loire-Atlantique 6, France, 44000 Germany Universitätsklinikum Tübingen Tübingen, Germany, 72076 United Kingdom Central Manchester University Hosptial Manchester, Greater Manchester, United Kingdom, M13 9WL Collapse << |
| NCT02411851 | Actinic Keratoses | Phase 1 | Completed | - | United States, New York ... more >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Collapse << |
| NCT02990221 | Actinic Keratosis | Phase 4 | Active, not recruiting | July 2018 | Italy ... more >> Second University of Naples Naples, Italy, 80131 Collapse << |
| NCT02421471 | - | - | Completed | - | Korea, Republic of ... more >> Department of Dermatology, Korea University Anam Hospital Seoul, Korea, Republic of Collapse << |
| NCT01600014 | - | - | Completed | - | - |
| NCT02473848 | Actinic Keratosis | Phase 3 | Terminated(Lack of enrolment) | - | Switzerland ... more >> Dermatology Department University Hospital Zürich Zürich, Switzerland, 8091 Collapse << |
| NCT01703078 | Actinic Keratosis | Phase 1 | Completed | - | Australia, Queensland ... more >> Dermatology Department Woolloongabba, Queensland, Australia, 4102 Collapse << |
| NCT00852137 | Actinic Keratosis | Phase 2 | Completed | - | United States, Texas ... more >> DermResearch, Inc. Austin, Texas, United States, 78759 Collapse << |
| NCT02716714 | - | - | Completed | - | - |
| NCT02354391 | Actinic Keratosis | Phase 2 | Active, not recruiting | December 2018 | - |
| NCT01787383 | Actinic Keratosis | Phase 3 | Completed | - | Italy ... more >> Clinica Dermatologica dell'Università di Modena e Reggio Emilia Modena, Italy, 41124 Collapse << |
| NCT02716714 | Actinic Keratosis | Phase 4 | Completed | - | Korea, Republic of ... more >> Korea University Ansan Hospital Ansan-si, Gyeonggi-do, Korea, Republic of, 15355 Collapse << |
| NCT03115476 | Actinic Keratoses ... more >> Squamous Cell Carcinoma Collapse << | Phase 3 | Terminated(Study halted premat... more >>urely and will not resume; participants are no longer being examined.) Collapse << | - | - |
| NCT02748902 | Verruca Vulgaris ... more >> Common Warts Collapse << | Phase 1 | Completed | - | United States, California ... more >> Therapeutics Clinical Research San Diego, California, United States, 92123 Collapse << |
| NCT02251652 | - | - | Completed | - | - |
| NCT02251652 | Actinic Keratoses | Phase 4 | Completed | - | United States, New York ... more >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 11370 Collapse << |
| NCT01926496 | Actinic Keratosis (AK) | Phase 4 | Active, not recruiting | October 2019 | - |
| NCT02594436 | - | - | Completed | - | Greece ... more >> Office Based Physician Athens, Peristeri, Greece, 12134 Collapse << |
| NCT02866695 | Actinic Keratosis | Phase 4 | Completed | - | United States, California ... more >> UCSF Dermatology San Francisco, California, United States, 94115 Collapse << |
| NCT01787383 | - | - | Completed | - | - |
| NCT01836367 | Actinic Keratosis | Phase 1 | Completed | - | United States, New York ... more >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Collapse << |
| NCT03452566 | Actinic Cheilitis | Phase 1 Phase 2 | Not yet recruiting | April 2020 | - |
